Sophisticated computer simulations can support effective science-based evaluations to facilitate better governance of the marine space with evidence-based policies. We developed a range of spatial fisheries models, integrating biological with fishers´decision-making dynamics and management for assessing the management of multiple activities. We present the outcomes of case-specific evaluations with different ecological and socio-economic characteristics i.e. Adriatic, Ionian, Black, Baltic and Celtic Seas, and priorities like fisheries, aquaculture, offshore wind energy or conservation areas. For each case, we applied the DISPLACE agent-based modeling platform for simulating bioeconomic dynamics and clarifying options for sustainable and viable fisheries in presence of other marine sectors. The work is ongoing and we foresee clear outcomes delivered by mid-2019.